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multi-joint exercises allow for the largest loads. It's important to teach new trainees how to recruit high threshold motor units in order to build strength and size. But even more important, the aforementioned exercises build intermuscular coordination at a significantly faster rate than single-joint, isolation exercises.
Overall, trainees' motor skills are greatly improved with compound exercises. When trainees perform nothing but single-joint, machine-based exercises, their motor skills end up being a mess. Since compound exercises are more challenging to the central nervous system (CNS), they're the ideal choice.