Sounds like you're doing a lot of full-body exercise. I recommend working different muscle groups on different days so you can give past muscle groups time to rest. Remember:
Muscles grow at rest, not while you work out.
If I ever combine leg exercises with other workouts, I always do them last, since they're very important to a number of other exercises and you want them at the top of their game. I once made the mistake of working my legs before my cardio -- I couldn't run.
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Am I doing something wrong if I'm unable to do an exercise for a particular muscle group due to an untargeted muscle being fatigued?
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You should altenate exercises so the muscle groups fatigue together. E.g., do a set of triceps, do a set of biceps, a set of triceps, a set of biceps, etc.
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Finally, should I do reps until failure for every exercise in every set? Because at the moment I only achieve failure in the last set of my workout. And does this mean I should rest a while between exercises and sets so that I get failure at the same point each time (rather than the reps decreasing)?
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At the end of a set, yes, you should have reached muscle failure. Try to find that sweet spot between weight and reps.
If you want to grow muscle faster and strength not as quickly, try to reach muscle failure in 20 - 30 reps with very little rest in between.
If you want to gain real strength but not necessarily increase size as quickly, try to reach muscle failure in 6 - 12 reps with plenty of rest in between.