first off, its 'effects'...not 'affects'.
secondly, Creatine helps your body process energy. that's all it does. a side effect is water retention, but most don't notice any change in appearance, just an increase of a pound or two of water weight.
I'm not sure what you think creatine does, but it's not any sort of miracle powder.
Most supplement don't do what they claim (NO2 products for example). Anything beyond that is going to fall under anabolic steriods, pro-hormones or pro-steriods...and if they are real, they are drugs and likely illegal because of the side effects associated with them.